Substituted benzimidazoles: antiviral activity and synthesis of nucleosides
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چکیده
منابع مشابه
Synthesis, antiviral and antitumor activity of 2-substituted-5-amidino-benzimidazoles.
We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities. The most pronounced antiproliferative activity was shown with compounds 6 and 9, having imidazolinylamidino-substituent. Int...
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The metal complexes of nine 2-substituted-1H-benzimidazoles (I-IX) with Ni(II), Pd(II), Cu(II), Ag(I), Zn(II) salts were synthesized. The compounds were characterized by melting point, analytical data, IR spectroscopy and magnetic susceptibility. The antimicrobial activity of the compounds was determined by the disk diffusion method in Mueller-Hinton Agar on Staphylococcus aureusATCC 6538, Stap...
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Emerson and associates (1) noted that 2,5-dimethylbenzimidazole appeared to act as a growth depressant when fed to rats in tests of compounds for vitamin Blz-like activity. This property was not exhibited by benzimidazole or any of the other monoor dimethylbenzimidazoles studied. They remarked that 2,5-dimethylbenzimidazole might have “inhibitor activity.” 2,5-Dimethylbenzimidazole inhibited re...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2008
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0010.319